Inflammatory and Tissue Remodeling Urinary Biomarkers before and after Mid Urethral Sling Surgery for Stress Urinary Incontinence
Identifieur interne : 005361 ( Main/Exploration ); précédent : 005360; suivant : 005362Inflammatory and Tissue Remodeling Urinary Biomarkers before and after Mid Urethral Sling Surgery for Stress Urinary Incontinence
Auteurs : Toby C. Chai [États-Unis] ; Holly E. Richter [États-Unis] ; Pamela Moalli [États-Unis] ; Susan Keay [États-Unis] ; Joseph Biggio [États-Unis] ; WENJUN ZONG [États-Unis] ; Teresa Curto [États-Unis] ; Hae-Young Kim [États-Unis] ; Anne M. Stoddard [États-Unis] ; John W. Kusek [États-Unis]Source :
- The Journal of urology [ 0022-5347 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Chirurgie.
English descriptors
- KwdEn :
Abstract
Purpose: Urinary biomarkers were measured in women at baseline and 1 year after surgery for stress urinary incontinence, and associations with clinicodemographic covariates and outcomes were analyzed. Materials and Methods: Preoperative and postoperative urine specimens from 150 women were assayed for inflammatory biomarkers (tumor necrosis factor-α, interferon-γ, interleukin-1β, interleukin-6, interleukin-10, interleukin-12p70, interleukin-17 and nerve growth factor) and tissue remodeling biomarkers (collagenase activity, matrix metalloproteinases-1, 2, 9 and 13, and NTx [N-telopeptide cross-linked collagen], epidermal growth factor and heparin-binding epidermal growth factor-like growth factor). Paired t-tests were used to compare changes in biomarkers during 1 year (significance p <0.05). Linear regression models correlated baseline and changes in biomarker levels with covariates (significance p ≤0.001). Logistic regression models, controlling for age, were used to analyze associations of baseline and changes in biomarker levels with surgical failure (significance p <0.05). Results: During 1 year interleukin-12p70 decreased (mean ± SD 0.53 ± 1.4 to 0.28 ± 0.62 pg/mg creatinine, p = 0.04) and nerve growth factor increased (0.034 ± 0.046 to 0.044 ± 0.060 pg/ml/mOsm, p = 0.03). Baseline NTx level per mg creatinine was positively associated with age and postmenopausal status (p = 0.001), and negatively associated with current estrogen use (p = 0.0001). Baseline collagenase activity per mg creatinine was positively associated with age (p = 0.001). Epidermal growth factor per mOsm, NTx per mOsm and interferon-γ per mOsm were negatively correlated with age, current estrogen use and UDI (Urogenital Distress Inventory)-irritative subscale score, respectively (p ≤0.001). Subjects with lower baseline NTx per mg creatinine were less likely to experience surgical failure (OR 0.49, 95% CI 0.26-0.93, p = 0.03). Changes in biomarker levels were not associated with any covariates or surgical failure. Conclusions: Stress urinary incontinence surgery was significantly less likely to fail in women with lower baseline NTx levels. Studies are needed to validate NTx as a possible independent biomarker for stress urinary incontinence surgery outcomes.
Affiliations:
- États-Unis
- Alabama, Maryland, Massachusetts, Pennsylvanie
- Baltimore, College Park (Maryland), Pittsburgh
- Université de Pittsburgh, Université du Maryland
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biological indicator</term>
<term>Biological marker</term>
<term>Inflammation</term>
<term>Methodology</term>
<term>Nephrology</term>
<term>Procedure</term>
<term>Prognosis</term>
<term>Remodeling</term>
<term>Sling operation</term>
<term>Stress</term>
<term>Surgery</term>
<term>Technique</term>
<term>Tissue</term>
<term>Treatment</term>
<term>Urethra</term>
<term>Urinary incontinence</term>
<term>Urinary stress incontinence</term>
<term>Urine</term>
<term>Urology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Indicateur biologique</term>
<term>Inflammation</term>
<term>Tissu</term>
<term>Urine</term>
<term>Marqueur biologique</term>
<term>Urètre</term>
<term>Incontinence urinaire d'effort</term>
<term>Incontinence urinaire</term>
<term>Stress</term>
<term>Chirurgie</term>
<term>Technique</term>
<term>Méthodologie</term>
<term>Procédure</term>
<term>Pronostic</term>
<term>Traitement</term>
<term>Néphrologie</term>
<term>Urologie</term>
<term>Remodelage</term>
<term>Intervention de fronde</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Purpose: Urinary biomarkers were measured in women at baseline and 1 year after surgery for stress urinary incontinence, and associations with clinicodemographic covariates and outcomes were analyzed. Materials and Methods: Preoperative and postoperative urine specimens from 150 women were assayed for inflammatory biomarkers (tumor necrosis factor-α, interferon-γ, interleukin-1β, interleukin-6, interleukin-10, interleukin-12p70, interleukin-17 and nerve growth factor) and tissue remodeling biomarkers (collagenase activity, matrix metalloproteinases-1, 2, 9 and 13, and NTx [N-telopeptide cross-linked collagen], epidermal growth factor and heparin-binding epidermal growth factor-like growth factor). Paired t-tests were used to compare changes in biomarkers during 1 year (significance p <0.05). Linear regression models correlated baseline and changes in biomarker levels with covariates (significance p ≤0.001). Logistic regression models, controlling for age, were used to analyze associations of baseline and changes in biomarker levels with surgical failure (significance p <0.05). Results: During 1 year interleukin-12p70 decreased (mean ± SD 0.53 ± 1.4 to 0.28 ± 0.62 pg/mg creatinine, p = 0.04) and nerve growth factor increased (0.034 ± 0.046 to 0.044 ± 0.060 pg/ml/mOsm, p = 0.03). Baseline NTx level per mg creatinine was positively associated with age and postmenopausal status (p = 0.001), and negatively associated with current estrogen use (p = 0.0001). Baseline collagenase activity per mg creatinine was positively associated with age (p = 0.001). Epidermal growth factor per mOsm, NTx per mOsm and interferon-γ per mOsm were negatively correlated with age, current estrogen use and UDI (Urogenital Distress Inventory)-irritative subscale score, respectively (p ≤0.001). Subjects with lower baseline NTx per mg creatinine were less likely to experience surgical failure (OR 0.49, 95% CI 0.26-0.93, p = 0.03). Changes in biomarker levels were not associated with any covariates or surgical failure. Conclusions: Stress urinary incontinence surgery was significantly less likely to fail in women with lower baseline NTx levels. Studies are needed to validate NTx as a possible independent biomarker for stress urinary incontinence surgery outcomes.</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Alabama</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Pennsylvanie</li>
</region>
<settlement><li>Baltimore</li>
<li>College Park (Maryland)</li>
<li>Pittsburgh</li>
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<li>Université du Maryland</li>
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<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Chai, Toby C" sort="Chai, Toby C" uniqKey="Chai T" first="Toby C." last="Chai">Toby C. Chai</name>
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<name sortKey="Biggio, Joseph" sort="Biggio, Joseph" uniqKey="Biggio J" first="Joseph" last="Biggio">Joseph Biggio</name>
<name sortKey="Curto, Teresa" sort="Curto, Teresa" uniqKey="Curto T" first="Teresa" last="Curto">Teresa Curto</name>
<name sortKey="Keay, Susan" sort="Keay, Susan" uniqKey="Keay S" first="Susan" last="Keay">Susan Keay</name>
<name sortKey="Kim, Hae Young" sort="Kim, Hae Young" uniqKey="Kim H" first="Hae-Young" last="Kim">Hae-Young Kim</name>
<name sortKey="Kusek, John W" sort="Kusek, John W" uniqKey="Kusek J" first="John W." last="Kusek">John W. Kusek</name>
<name sortKey="Moalli, Pamela" sort="Moalli, Pamela" uniqKey="Moalli P" first="Pamela" last="Moalli">Pamela Moalli</name>
<name sortKey="Richter, Holly E" sort="Richter, Holly E" uniqKey="Richter H" first="Holly E." last="Richter">Holly E. Richter</name>
<name sortKey="Stoddard, Anne M" sort="Stoddard, Anne M" uniqKey="Stoddard A" first="Anne M." last="Stoddard">Anne M. Stoddard</name>
<name sortKey="Wenjun Zong" sort="Wenjun Zong" uniqKey="Wenjun Zong" last="Wenjun Zong">WENJUN ZONG</name>
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